Breakthrough Spring 2017 | Page 73

billion bases of

3.2 DNA make up the human genome

Ventures wishing to locate in the BIC should be undertaking research or demonstrate innovative thinking around products and services in genomics and biodata
The Wellcome Trust Sanger Institute is now a worldleader in genomics research
Collaboration and the sharing of data are fundamental tenets of the Institute , with collaborators in the neighbouring European Bioinformatics Institute ( EBI ) and across the globe . Open-access databases are freely available for other scientists to use , while Wellcome Genome Campus Connecting Science enables people to explore genomic science .
The Sanger Institute is known for its large-scale projects and data production , and the campus has the largest sequencing facility in Europe , which was officially opened by the Prime Minister in November 2016 . This scale , alongside collaboration with clinicians and researchers in other fields enables projects such as the £ 20 million Grand Challenge project studying the genomes of 5,000 cancer patients from five continents to better understand what causes cancer , and the international Human Cell Atlas initiative , which aims to identify and map every cell in the body to understand health and disease .
Innovation is a key component of the Genome Campus ’ success , and companies such as Congenica , and Microbiotica were formed out of scientific breakthroughs at the Sanger Institute . These and other genomics companies are housed in the
© Sanger Institute : Genome Research Ltd .
new campus Biodata Innovation Centre ( or BIC ).
The campus also houses the centralised sequencing facility for Genomics England . This aims to sequence 100,000 genomes from NHS patients and their families and will help personalise medical treatment .
Over 2,000 people now work at the Genome Campus , and the proximity of researchers , innovators and industrial collaborators ensures an excellent flow of information and ideas .
More information is available about the Wellcome Genome Campus at www . wellcomegenomecampus . org and the Sanger Institute at www . sanger . ac . uk
Championing open data The numbers on screen are always changing : expanding bubbles pop up across a map of the world . The screen is one of many on the Wellcome Genome Campus showing how many users are accessing the data services of the European Bioinformatics Institute ( EMBL-EBI ), right now .
EMBL-EBI has a mission to make scientific data readily accessible to researchers working in biomedicine , pharmaceuticals , biodiversity , ecology , agri-food and many other disciplines – in both corporate and academic settings . Based on the Genome Campus in the Cambridge UK biocluster , EMBL-EBI is at the centre of one of the highest concentrations of genomics and big-data expertise in the world .
The institute manages public life-science data on a very large scale , making it freely available to researchers throughout the
world . With data centres set to handle over 100 petabytes ( 100 million gigabytes ) of data , it has become a cornerstone of digital biology , enabling and enriching international scientific collaboration . The data held at EMBL-EBI would be impossible to replicate by most private or public organisations .
EMBL-EBI works with diverse scientific communities and its Industry Programme ensures that its infrastructure , tools and training are keeping pace with the rapidly changing research environment . The institute is a champion for open data in the life sciences , which can reduce the length of clinical trials , help people better understand the drivers of disease and expose unexpected research avenues .
In any day-to-day operation , it can be easy to lose track of the big picture . When that happens , one glance at the screens around campus is enough to remind you just how fast the appetite for open data is growing in the life sciences . That ’ s good for discovery , good for companies and , ultimately , good for society .
Connecting Science The research taking place on campus is cutting-edge and has broad implications for everyone . Wellcome Genome Campus
The Sanger Institute was built to house the Human Genome Project
© Sanger Institute : Genome Research Ltd .
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